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. Author manuscript; available in PMC: 2012 Feb 3.
Published in final edited form as: Neuroscience. 2010 Dec 1;174:1–9. doi: 10.1016/j.neuroscience.2010.11.053

Figure 2.

Figure 2

Group III mGluR receptors inhibit spontaneous EPSCs in dissociated medial NTS neurons. In a representative neuron (A), mGluR III antagonist MSOP (200 µM) rapidly increased the rate of sEPSCs. Activation of mGluR III with the agonist L-AP4 (10 µM) nearly eliminated sEPSCs. Diary plot of sEPSC events (B) from the neuron in A shows that mGluR III drug actions were rapid and readily reversed by washing. Across neurons (C), relative mean sEPSC frequency decreased significantly during mGluR III activation and increased during antagonism (* indicates significant differences from control, p<0.01; n=8). Amplitudes of sEPSCs were not changed (not shown). Bicuculline (100 µM) was present throughout to block IPSCs.