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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Pediatr Res. 2011 Feb;69(2):101–105. doi: 10.1203/PDR.0b013e3182055237

Figure 4.

Figure 4

TLR signaling pathway in pneumococcal otitis media of rats. All genes involved in the TLR signaling pathway were evaluated by GeneSifter using Z-score as a parameter. Pn6A vs. PBS control had Z-scores (2.41 for up-regulated genes and −1.85 for down-regulated genes) of TLR signaling pathway (A, black bar, up-regulated; gray bar, down-regulated). Similar changes were observed in the MAPK signaling pathway. Dotted line in A indicates a normal range for Z-scores (A). Microarray heat maps demonstrated that the TLR signaling pathway genes and related genes were up-regulated (IL-1β, IL-6, MIP-1α, TLR4, TLR2, p38MAPK, jun, IκBα) or down-regulated (MAPK14 and PI3 K p85β) (B) in the rat middle ear mucosa after Pn6A challenge for 3–14 d. Upward and downward rows indicate up-regulated and down-regulated genes, respectively.