Table 2.

Regional differences in mean gray matter density between the currently depressed subjects with major depression (n=58) compared to healthy controls (n=107) and currently remitted subjects (n=27)

Region	k	FWE	T	Local Maximum
HC > dMDD
Right Superior Frontal G	2157	0.071	4.04	12	49	41
Right Superior Frontal G			3.77	11	56	36
Right Superior Frontal G			3.17	22	35	46
Left Middle Frontal G	2736	0.038	3.72	−27	28	42
Left Superior Frontal G			3.60	−32	36	30
Left Superior Frontal G			3.45	−21	32	47
rMDD > dMDD
Left Frontal Polar Cortex	95942	<0.001	5.31	−28	50	22
Right Superior Temporal G			5.22	50	3	−7
Left Insula			5.19	−33	0	−3
Left Precuneus	2974	0.03	4.32	−13	−42	49
Precuneus			3.88	−3	−50	47
Left Precuneus			3.77	−6	−56	55
Cuneus	6240	<0.001	4.27	−3	−91	12
Left Cuneus			4.05	−7	−71	10
Right Cuneus			3.90	8	−85	8
Right Inferior Parietal Lobule	4213	0.009	4.19	40	−45	49
Right Inferior Parietal Lobule			3.68	51	−52	41
Right Superior Parietal Lobule			3.65	36	−57	51
Right Precuneus	1912	0.094	4.04	14	−81	42
Right Precuneus			3.45	11	−68	36
Right Precuneus			3.43	16	−62	40
rMDD > HC
Left Putamen/Insula	6705	0.001	4.70	−33	−5	−5
Left Putamen/Insula			4.61	−34	−14	−4
Left Superior Temporal G			3.50	−48	−4	−11
Right Putamen/Insula	1993	0.085	4.49	36	−11	−5
Right Inferior Frontal G	2164	0.070	4.15	40	28	1
Right Putamen/Insula			3.55	24	24	4
Right Inferior Parietal Lobule	3237	0.023	4.14	61	−36	23
Right Superior Temporal G			4.14	58	−23	12
Right Postcentral G			3.61	58	−6	14

Abbreviations: G, gyrus; k, number of voxels in the cluster; HC, healthy control subjects; dMDD, currently depressed subjects; rMDD, currently remitted subjects; FWE, familywise error corrected at the cluster level; x, y, z show coordinates in mm from the sterotaxic origin, with positive y denoting anterior, positive z superior, and positive x to the right of midline (Talairach and Tournoux, 1988); T, T-score