Table 3.

Regional differences in mean gray matter volume between the currently depressed subjects with major depressive disorder (n=58) compared to healthy controls (n=107) and currently remitted MDD subjects (n=27)

Region	k	FWE	T	Local Maximum
HC > dMDD
Left Inferior Frontal G	3330	0.017	4.24	−47	24	17
Left Inferior Frontal G			3.74	−49	38	10
Right Superior Frontal G			3.59	−37	36	30
Right Middle Frontal G	1799	0.091	3.97	51	41	16
Right Superior Frontal G			3.94	40	41	30
Right Superior Frontal G			3.55	29	44	16
rMDD > dMDD
Right Superior Temporal G	81120	<0.001	5.56	49	4	−7
Subgenual Anterior Cingulate G			5.00	−2	9	−16
(Infralimbic Cortex)
Right Subgenual Anterior Cingulate G			4.89	13	25	−7
Left Superior Frontal G	7667	<0.001	4.56	−28	50	22
Left Middle Frontal G			4.21	−42	20	40
Left Inferior Frontal G			4.20	−48	24	20
rMDD > HC
Right Subgenual Anterior Cingulate G	2982	0.024	4.95	13	24	−8
Right Pregenual Anterior Cingulate G			4.06	7	31	5
Pregenual Anterior Cingulate G			3.54	−2	31	5

Abbreviations: G, gyrus; k, number of voxels in the cluster; HC, healthy control subjects; dMDD, currently depressed subjects; rMDD, currently remitted subjects; FWE, familywise error corrected at the cluster level; x, y, z show coordinates in mm from the sterotaxic origin, with positive y denoting anterior, positive z superior, and positive x to the right of midline (Talairach and Tournoux, 1988); T, T-score