Table 1.
Characteristics of pravastatin supplemented and non-supplemented SHRs and WKYs.
| SHR non-supplemented (n = 32) | SHR Pravastatin supplemented (n = 41) | WKY non-supplemented (n = 20) | WKY Pravastatin supplemented (n = 20) | |
|---|---|---|---|---|
| Pravastatin intake (mg/kg) | 0 | 9.42 ± 0.15 (n = 25) | 0 | 10.00 ± 0.20* (n = 12) |
| Serum cholesterol (mmol/l) | 1.0 ± 0.1 (n = 7) | 1.1 ± 0.3 (n = 7) | 2.1 ± 0.1** (n = 7) | 1.6 ± 0.1* (n = 7) |
| Ventricular weight/body weight (×10−3) | 3.23 ± 0.03* (n = 15) | 3.27 ± 0.04* (n = 25) | 2.94 ± 0.03 (n = 12) | 2.88 ± 0.04 (n = 12) |
| Mean ABP (mmHg) | 173 ± 4* (n = 11) | 172 ± 4* (n = 13) | 86 ± 3 (n = 8) | 83 ± 4 (n = 8) |
| Heart rate in-vivo (bpm) | 353 ± 11** (n = 11) | 340 ± 9* (n = 16) | 287 ± 5 (n = 8) | 281 ± 12 (n = 8) |
| Heart rate in-vitro (bpm) | 231 ± 10 (n = 19) | 241 ± 7 (n = 16) | 252 ± 14 (n = 8) | 258 ± 6*** (n = 8) |
*SHR vs. WKY p < 0.05. **SHR vs. WKY and pravastatin supplemented vs. non-supplemented p < 0.05. ***SHR vs. WKY pravastatin supplemented only p < 0.05.