Figure 2.

Effect of strain differences and Hfe genotype on hepatic iron concentration. Hepatic nonheme iron concentrations were measured in wild-type (Hfe +/+), heterozygote knockout (Hfe +/−), and knockout (Hfe −/−) mice from three inbred mouse strains: C3H (hatched bars), C57BL/6 (B6, solid bars), and AKR (slashed bars). Data are presented as the mean ± SEM. Differences across strains within each genotype and across genotypes within each strain were determined separately by a one-way ANOVA. P < 0.05 across strains within genotype: bars 1 vs. 2, bars 1 vs. 3, bars 2 vs. 3, bars 4 vs. 5, bars 4 vs. 6, bars 5 vs. 6, bars 7 vs. 8, bars 7 vs. 9, and bars 8 vs. 9. P < 0.05 across genotypes within strain: bars 1 vs. 7, bars 2 vs. 8, bars 3 vs. 6, bars 3 vs. 9, bars 4 vs. 7, bars 5 vs. 8, bars 6 vs. 9.