Fig. 1.

Linkage disequilibrium among AKT1 SNPs within the FAMUSS population and SHS. Linkage disequilibrium is plotted for African-Americans, Asians and European Americans of the FMS cohort. The LD was calculated between each pair of SNPs using the r ² measurement and haplotype frequencies were estimated using the online program PHASE, which uses genotype data to determine the phase of the chromosomes and thus haplotype structure and frequency. The SNPs from Table 1 are plotted on the X and Y axes. A color scale is then used to plot the LD between any two SNPs. Blue equals an r ² of zero, red equals an r ² of 1.0. The SNPs of H1/H2 are in red text. All three of the SNPs are in high LD with each other as shown by the red blocks