Table 3.
Plant pathways that are affected by mutations in or de-regulations of genes encoding proteins that function in nucleo-cytoplasmic transport of macromolecules
| Genes | Comments | Pathways affected by mutation or de-regulation | References |
|---|---|---|---|
| MOS6 (IMPa-3) | Encodes an adapter for nuclear import of NLS proteins | Immune response | Palma et al. (2005) |
| IMPa-4 | Encodes an adapter for nuclear import of NLS proteins | Agrobacterium tumefaciens-mediated transformation | Bhattacharjee et al. (2008) |
| SAD2 | Encodes an NTR of the importin beta family (RanBP7/8 ortholog) | ABA response, cold stress, osmotic stress, UV-B response | Zhao et al. (2007); Verslues et al. (2006) |
| XPO1A, XPO1B | Encode NTRs of the importin beta family | Gametophyte development | Blanvillain et al. (2008) |
| Hasty/Exportin 5 | Encodes an NTR of the importin beta family | Pre-miRNA biogenesis/export defect, many developmental pathways incl. flowering time | Bollman et al. (2003); Park et al. (2005) |
| Paused/Exportin-T | Encodes an NTR of the importin beta family | tRNA export defect, many developmental pathways incl. flowering time | Hunter et al. (2003); Li and Chen (2003); Park et al. (2005) |
| Ran1, Ran2 | Encode GTPase Ran (overexpession in Arabidopsis and tobacco) | Auxin response, cell division, osmotic and salt stress | Wang et al. (2006); Zang et al. (2010) |
| RanBP1c | Encodes a regulatory protein of the GTPase Ran (antisense overexpession) | Auxin response | Kim et al. (2001) |
| RanGAP1 | Regulatory protein of the GTPase Ran (sense overexpession) | Cell division, cytokinesis | Xu et al. (2008) |
| LOS4/Cryophyte | Encodes a DEAD box RNA helicase, putative yeast Dbp5 ortholog | mRNA export defect, cold stress | Gong et al. (2002, 2005) |
| CBP20, ABH1/CBP80 | Encode proteins of the nuclear Cap-binding complex (CBC) | ABA response, flowering time | Hugouvieux et al. (2002); Bezerra et al. (2004); Papp et al. (2004a, b) |
| Rae1 (Nicotiana benthamiana) | Encodes a putative ortholog of the yeast RNA export factor Rae1p (RNAi-mediated silencing) | mRNA export defect, growth defects, cell division | Lee et al. (2009) |
| AtTPR/AtNUA | Encodes a nucleoporin | mRNA export defect, flowering time | Jacob et al. (2007); Xu et al. (2007a, b) |
| Nup85 (Lotus japonicus) | Encodes a nucleoporin | Bacterial and fungal symbiosis | Saito et al. (2007) |
| Nup133 (Lotus japonicus) | Encodes a nucleoporin | Bacterial and fungal symbiosis | Kanamori et al. (2006) |
| MOS7 (AtNup88) | Encodes a nucleoporin | Immune response | Cheng et al. (2009) |
| MOS3/SAR3 (AtNup96) | Encodes a nucleoporin | mRNA export defect, immune response, auxin response, flowering time | Parry et al. (2006); Zhang and Li (2005) |
| SAR1 (AtNup160) | Encodes a nucleoporin | mRNA export defect, auxin response, flowering time, cold stress | Dong et al. (2006); Parry et al. (2006) |
| AtNup1 | Encodes a nucleoporin | mRNA export defect, many developmental pathways | Lu et al. (2010) |
| AtTHP1 | Encodes a homolog of a component of the yeast TREX-2 complex | mRNA export defect, many developmental pathways | Lu et al. (2010) |
If not stated otherwise, the genes are from Arabidopsis thaliana
ABA abscisic acid; NTR nuclear transport receptor