Table 1.
Selection of the preferred model using SAEM given the maraviroc monotherapy study design (n = 50)
Model | With inter-individual variability on LagE and/or ke0? | Number of times selected as preferred model [%] |
---|---|---|
No lag time | No | 0 [0] |
No effect compartment | ||
Lag time only | No | 48 [96] |
Lag time only | Yes | 4 [8]a |
Effect compartment only | No | 0 [0] |
Effect compartment only | Yes | 0 [0] |
With lag time and effect compartment | No | 6 [12]b |
With lag time and effect compartment | Yes | 0 [0] |
aOnly 2 coincided with the 48 runs from the lag time only model without ω[LagE]
bAll 6 coincided with the 48 runs from the lag time only model without ω[LagE]