Table 2.
Factors associated with the development of intrahepatic cholangiocarcinoma in blood donors according to Cox proportional hazard analysis
| Variable | n | ICC | Hazard ratio | 95%CI |
|---|---|---|---|---|
| Age at blood donation (years) | ||||
| 40–49 | 90 223 | 2 | 1.00 | |
| 50–54 | 35 308 | 4 | 5.90 | 1.08–32.31 |
| 55–59 | 20 668 | 4 | 11.07 | 1.98–61.79 |
| 60–64 | 8615 | 1 | 6.61 | 0.59–74.59 |
| Sex | ||||
| Male | 84 205 | 7 | 1.00 | |
| Female | 70 609 | 4 | 0.79 | 0.22–2.82 |
| ALT level (KU) at blood donation | ||||
| 19 or lower | 127 757 | 7 | 1.00 | |
| 20–39 | 23 666 | 2 | 1.47 | 0.29–7.36 |
| 40 or over | 3391 | 2 | 8.30 | 1.47–46.83 |
| Cholesterol level at blood donation* | ||||
| 200 mg/dL or higher | 67 706 | 3 | 1.00 | |
| 140–199 | 82 575 | 8 | 2.36 | 0.60–9.26 |
| 139 or lower | 4533 | 0 | – | – |
| Hepatitis B/C virus infection | ||||
| All negative | 150 368 | 8 | 1.00 | |
| HCV-Ab + | 1927 | 1 | 2.63 | 0.25–27.73 |
| HBs Ag+ | 2519 | 2 | 8.56 | 1.33–55.20 |
None of the subjects was positive for human immunodeficiency virus or human T-cell lymphotropic virus type 1. Age (4 categories), sex, serum ALT level at blood donation (3 categories), and serum cholesterol level at blood donation (3 categories) were included as independent variables in the Cox proportinal hazard analysis. ALT, alanine aminotransferase; Cl, confidence interval; HBsAg+, tested positive for Hepatitis B surface antigen and negative for Hepatitis C virus antibody; HCV-Ab+, tested positive for anti Hepatiis C virus antibody and negative for Hepatitis B surface antigen; ICC, intrahepatic cholangiocarcinoma; KU, Karmen Unit.