Table 2.
Mean endoglin and vascular endothelial growth factor levels in gastroenteropancreatic neuroendocrine tumors in relation to clinicopathological parameters
|
Endoglin (ng/mg) |
VEGF (pg/mg) |
|||||||
| n | mean | SE | P | n | mean | SE | P | |
| Tissues | ||||||||
| Normal | 38 | 12.1 | 2.0 | < 0.012 | 38 | 75.0 | 9.5 | < 0.012 |
| Tumor | 27 | 26.8 | 4.5 | 26 | 316.8 | 46.0 | ||
| Tumor type | ||||||||
| Carcinoid | 8 | 35.3 | 11.4 | 0.37 | 8 | 354.9 | 72.0 | 0.67 |
| Functional PNET | 14 | 25.4 | 4.7 | 13 | 274.4 | 46.7 | ||
| Non-functional PNET | 5 | 16.8 | 8.7 | 5 | 366.2 | 186.8 | ||
| Origin | ||||||||
| Primary tumors | 19 | 18.8 | 3.9 | < 0.012 | 18 | 293.2 | 52.0 | 0.45 |
| Metastatic tumors | 8 | 45.7 | 9.0 | 8 | 369.9 | 95.8 | ||
| WHO classification | ||||||||
| Well-differentiated NETs | 6 | 7.6 | 5.2 | 0.0212 | 6 | 200.2 | 52.8 | 0.211 |
| Well-differentiated NECs | 20 | 32.9 | 4.0 | 19 | 328.5 | 60.2 | ||
| Poorly-differentiated NECs | 1 | 19.0 | ND | 1 | 795.0 | ND | ||
| Primary tumors: metastases | ||||||||
| Present | 12 | 24.8 | 5.2 | 0.042 | 11 | 339.5 | 76.4 | 0.28 |
| Absent | 7 | 8.5 | 3.5 | 7 | 220.6 | 54.8 | ||
1
Result of unpaired t test to compare well-differentiated neuroendocrine tumors (NETs) with well-differentiated neuroendocrine carcinomas (NECs);
2
P values are considered statistically significant. VEGF: Vascular endothelial growth factor; PNET: Pancreatic neuroendocrine tumor; ND: Not described.