TABLE 6.
In vitro activity of seven antifungal compounds against Danish fungemia isolatesa
| Species | Antifungal agent (no. of isolates) | MIC range (μg/ml) | MIC50 (μg/ml) | MIC90 (μg/ml) | BP (S≤/R>) | % R |
|---|---|---|---|---|---|---|
| C. albicans | Amphotericin B (1,179) | 0.016-1 | 0.25 | 0.5 | 1/1 | 0 |
| Anidulafungin (282) | ≤0.03-0.06 | ≤0.03 | ≤0.03 | 0.015/0.015 | 0.4 | |
| Caspofungin (1,174) | 0.016-16 | 0.125 | 0.5 | 2/2 | 0.1 | |
| Fluconazole (1,183) | ≤0.125->16 | ≤0.125 | 0.5 | 2/4 | 0.6 | |
| Itraconazole (1,167) | ≤0.03->4 | 0.03 | 0.03 | 0.125/0.5 | 0.1 | |
| Voriconazole (1,121) | ≤0.03->4 | ≤0.03 | 0.06 | 0.125/0.125 | 0.3 | |
| Posaconazole (563) | ≤0.03->4 | ≤0.03 | 0.03 | 0.064/0.064 | 0.4 | |
| C. dubliniensis | Amphotericin B (65) | 0.008-0.5 | 0.06 | 0.25 | 1/1 | 0 |
| Anidulafungin (23) | ≤0.03-0.5 | ≤0.03 | ≤0.03 | 0.015/0.015 | 8.7 | |
| Caspofungin (65) | 0.03->32 | 0.25 | 1 | 2/2 | 3.1 | |
| Fluconazole (65) | ≤0.125->16 | 0.25 | 1 | 2/4 | 3.1 | |
| Itraconazole (65) | ≤0.03-0.125 | 0.03 | 0.03 | 0.125/0.5 | 0 | |
| Voriconazole (65) | ≤0.03-0.5 | ≤0.03 | ≤0.03 | 0.125/0.125 | 1.5 | |
| Posaconazole (38) | ≤0.03-0.06 | ≤0.03 | 0.06 | 0.064/0.064 | 0 | |
| C. glabrata | Amphotericin B (449) | 0.06-4 | 0.5 | 1 | 1/1 | 1.6 |
| Anidulafungin (104) | ≤0.03-1 | ≤0.03 | ≤0.06 | 0.064/0.064 | 2 | |
| Caspofungin (449) | 0.016-2 | 0.5 | 1 | 2/2 | 0 | |
| Fluconazole (455) | 0.5->16 | 8 | >16 | NA | NA | |
| Itraconazole (448) | ≤0.03->4 | 0.25 | 2 | 0.125/0.5 | 34.8 | |
| Voriconazole (436) | ≤0.03->4 | 0.25 | 2 | NA | NA | |
| Posaconazole (231) | ≤0.03->4 | 0.25 | 2 | NA | NA | |
| C. krusei | Amphotericin B (106) | 0.06-4 | 1 | 1 | 1/1 | 4.7 |
| Anidulafungin (28) | ≤0.03-0.06 | ≤0.03 | ≤0.03 | 0.125/0.125 | 0 | |
| Caspofungin (106) | 0.06-2 | 0.5 | 1 | 2/2 | 0 | |
| Fluconazole (106) | 8->16 | >16 | >16 | NA | NA | |
| Itraconazole (106) | 0.03-1 | 0.25 | 0.5 | 0.125/0.5 | 1.9 | |
| Voriconazole (104) | 0.06-2 | 0.25 | 0.25 | NA | NA | |
| Posaconazole (62) | 0.03-0.5 | 0.125 | 0.5 | NA | NA | |
| C. parapsilosis | Amphotericin B (82) | 0.06-1 | 0.5 | 1 | 1/1 | 0 |
| Anidulafungin (22) | 0.5-2 | 1 | 2 | NA | NA | |
| Caspofungin (83) | 0.25-16 | 2 | 4 | NA | NA | |
| Fluconazole (83) | ≤0.125->16 | 1 | 4 | 2/4 | 6.0 | |
| Itraconazole (83) | ≤0.03-0.25 | 0.06 | 0.125 | 0.125/0.5 | 0 | |
| Voriconazole (79) | ≤0.03-2 | ≤0.03 | 0.06 | 0.125/0.125 | 1.3 | |
| Posaconazole (44) | ≤0.03-0.25 | 0.03 | 0.06 | 0.064/0.064 | 2.3 | |
| C. tropicalis | Amphotericin B (103) | 0.016-2 | 0.5 | 1 | 1/1 | 1 |
| Anidulafungin (28) | ≤0.03-1 | ≤0.03 | ≤0.03 | 0.064/0.064 | 3.6 | |
| Caspofungin (104) | 0.03-2 | 0.25 | 1 | 2/2 | 0 | |
| Fluconazole (104) | ≤0.125->16 | 0.5 | 4 | 2/4 | 6.7 | |
| Itraconazole (104) | ≤0.03->4 | 0.03 | 0.25 | 0.125/0.5 | 3.8 | |
| Voriconazole (102) | ≤0.03->4 | ≤0.03 | 0.25 | 0.125/0.125 | 6.0 | |
| Posaconazole (55) | ≤0.03->4 | 0.03 | 0.125 | 0.064/0.064 | 18.2 | |
| Candida spp. | Amphotericin B (64) | 0.016-2 | 0.25 | 0.5 | 1/1 | 1 |
| Anidulafungin (20) | ≤0.03-1 | ≤0.03 | 1 | NA | NA | |
| Caspofungin (64) | 0.125-8 | 0.5 | 2 | 2/2 | 3.1 | |
| Fluconazole (64) | ≤0.125->16 | 4 | >16 | 2/4 | 45.3 | |
| Itraconazole (63) | ≤0.03->4 | 0.125 | 1 | 0.125/0.5 | 11.1 | |
| Voriconazole (61) | ≤0.03-4 | 0.125 | 0.5 | 0.125/0.125 | 37.7 | |
| Posaconazole (38) | ≤0.03-2 | 0.06 | 0.25 | 0.064/0.064 | 39.5 | |
| Other fungi | Amphotericin B (43) | 0.06->16 | 0.5 | 2 | 1/1 | 16.3 |
| Anidulafungin (7) | ≤0.03->4 | 0.125 | >4 | NA | NA | |
| Caspofungin (41) | 0.25->32 | 2 | 16 | NA | NA | |
| Fluconazole (43) | ≤0.125->16 | 8 | >16 | NA | NA | |
| Itraconazole (43) | 0.03->4 | 0.5 | >4 | 0.125/0.5 | 41.9 | |
| Voriconazole (42) | ≤0.03->4 | 0.25 | 2 | NA | NA | |
| Posaconazole (24) | 0.03->4 | 0.5 | >4 | NA | NA |
a
BP, breakpoint; S, sensitivity; R, resistance.