TABLE 1.
Significant associations between costly HLA-selected escape mutations and high-variability HLA-independent polymorphisms
| HXB2 position of HLA-selected escape mutation | Epitope (position of mutation) | Selecting HLA-B allele |
P value for indicated HXB2 position of HLA-independent polymorphisma |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 138 | 215 | 219 | 223 | 228 | 248 | 252 | 256 | |||
| 146 | ISW9 (−1) | 1510/5702/5703 | — | — | — | — | 2.0 × 10−3 | — | — | — |
| 147 | ISW9 (1) | 5702/5703 | — | — | — | 1.6 × 10−3 | — | — | — | 0.001 |
| 177 | TL9 (−3) | 81(01) | — | — | — | — | — | — | — | — |
| 182 | TL9 (3) | 4201/8101 | 7.4 × 10−6 | — | — | — | 3.6 × 10−5 | — | 9.1 × 10−4 | 2.2 × 10−3 |
| 186 | TL9 (7) | 8101 | — | — | — | — | — | — | — | 6.7 × 10−5 |
| 242 | TW10 (3) | 5702/5703/5801 | — | — | — | — | — | — | — | — |
| 247 | TW10 (8) | 5703 | — | — | — | — | — | — | 7.0 × 10−4 | 4.0 × 10−8 |
a
q was <0.2 for all associations reported as significant. —, not significant.