TABLE 3.
Influence of acute XMRV infection on blood parameters (4 weeks postinfection)a
| Parameterb | A7 | A8 | A9 | A11 | A12 | A13 | A14 | A15 | A16 | Normal rangec |
|---|---|---|---|---|---|---|---|---|---|---|
| SC | + | + | + | + | + | + | + | + | + | |
| WBC | 5.96 | 9.36 | 12.79 | 7.01 | 4.81 | 7.08 | 7.18 | 7.74 | 6.79 | 4.4-8.6 |
| LYM | 4.21 | 6.08 | 7.24 | 4.2 | 3.25 | 4.89 | 5.21 | 5.81 | 5.1 | 3.4-5.9 |
| MON | 0.23 | 0.06 | 0.59 | 0.04 | 0.09 | 0.04 | 0.58 | 0.35 | 0.14 | 0.01-0.32 |
| GRA | 1.52 | 3.22 | 4.97 | 2.77 | 1.48 | 2.14 | 1.39 | 1.58 | 1.54 | 0.4-2.9 |
| RBC | 9.13 | 11.08 | 9.54 | 10.43 | 10.36 | 10.76 | 9.93 | 10.37 | 11.13 | 9.1-12.1 |
| HGB | 14.3 | 18.2 | 15.7 | 17.4 | 16.3 | 17.8 | 15.6 | 16.2 | 16.3 | 14.3-19.2 |
| HCT | 39.93 | 49.23 | 41.95 | 49.01 | 44.33 | 49.15 | 40.42 | 47.249 | 44.54 | 38-52 |
| MCV | 44 | 44 | 44 | 47 | 43 | 46 | 41 | 46 | 40 | 40-45 |
| MCH | 15.7 | 16.5 | 16.4 | 16.7 | 15.7 | 16.5 | 15.7 | 15.6 | 14.6 | 14.8-16.8 |
| MCHC | 35.9 | 37 | 37.4 | 35.5 | 36.7 | 36.1 | 38.5 | 34.3 | 36.6 | 35.8-38.7 |
| PLT | 155 | 624 | 1,296 | 776 | 817 | 699 | 618 | 497 | 727 | 244-1042 |
Numbers above the normal range of control mice are in boldface. Numbers below the normal range of control mice are underscored.
WBC, LYM, MON, GRA, RBC, HGB, HCT, MCV, MCH, MCHC, and PLT represent the white blood cell count (109/liter), lymphocyte count (109/liter), monocyte count (109/liter), granulocyte count (109/liter), red blood cell count (1012/liter), hemoglobin level (g/dl), hematocrit (%), mean corpuscular volume (fl), mean corpuscular hemoglobin (pg), mean corpuscular hemoglobin concentration (g/dl), and platelet count (109/liter), respectively. XMRV seroconversion (SC) was confirmed (+) by Western blotting.
The 95% reference range was calculated as (mean − 1.96 × SD) to (mean + 1.96 × SD) using CBC data from 12 uninfected Mus pahari (see Table S1 in the supplemental material) and is shown as the normal range. SD, standard deviation.