TABLE 2.
Disease profile of HuMM mice inoculated with experimental sheep BSE inoculum 2
| Mouse no. | Survivala (days) | Clinical signs | Vacuolar pathology | Thioflavin | PrPd scoreb | Spleen IDEXXc |
|---|---|---|---|---|---|---|
| 1 | 377 | − | − | − | − | − |
| 2 | 414 | − | − | − | + | + |
| 3 | 422 | − | − | − | − | + |
| 4 | 434 | − | − | − | + | − |
| 5 | 463 | − | − | − | + | − |
| 6 | 514 | − | − | − | − | NAd |
| 7 | 568 | − | − | − | − | + |
| 8 | 568 | − | − | − | − | + |
| 9 | 568 | − | − | − | + | + |
| 10 | 583 | − | − | − | − | NA |
| 11 | 583 | − | − | − | + | + |
| 12 | 583 | − | − | − | + | + |
| 13 | 589 | − | − | − | − | − |
| 14 | 589 | − | − | + | ++ | + |
| 15 | 603 | − | − | − | ++ | + |
| 16 | 622 | − | − | − | ++ | + |
| 17 | 623 | − | − | + | ++ | − |
| 18 | 681 | − | − | + | +++ | NA |
| 19 | 687 | − | + | + | ++ | − |
| 20 | 692 | − | − | + | +++ | NA |
| 21 | 705 | − | − | + | +++ | NA |
| 22 | 723 | − | + | + | +++ | NA |
| 23 | 750 | − | + | + | +++ | − |
a
Animals died or were culled for welfare reasons.
b
PrP deposition scored as the following: −, no deposition; +, very low deposition; ++, low deposition; +++, moderate deposition.
c
An optical density reading above the positive threshold value for the IDEXX assay is represented as a plus.
d
NA, no spleen tissue available.