Table 1.
Measure | Baseline (n=14) | 3 days (n=12) | 3 weeks (n=10) | 6 weeks (n=9) |
---|---|---|---|---|
HDRS24 | 24.6 (5.6) | 13.0 (6.1)*** | 13.6 (7.6)*** | 11.1 (7.7)*** |
HAM-A | 13.1 (3.9) | 7.0 (4.3)*** | 8.0 (4.7)*** | 7.5 (3.5)*** |
RBANS | 97.8 (8.9) | 102.0 (14.9) | 103.0 (12.7) | 105.5 (7.4)* |
BDI | 27.8 (7.7) | 15.8 (11.2)*** | 18.3 (12.0)*** | 15.4 (11.4)*** |
Responders | 6 (43%) | 5 (36%) | 5 (36%) | |
Remitters | 4 (29%) | 5 (36%) | 4 (29%) |
Mean [SD] are for all available data; missing values were not imputed. Response and remission rates were calculated in an intent-to-treat fashion. Significance reflects comparison to baseline:
p< 0.05;
p<0.01;
p< 0.001.
Responders defined by ≥50% decrease in HDRS24; Remitters defined by HDRS24 ≤10. HRSD24=24-item Hamilton Depression Rating Scale; HAMA=Hamilton Rating Scale for Anxiety; BDI=Beck Depression Inventory; RBANS=Repeatable Battery for the Assessment of Neuropsychological Status (total score).