. Author manuscript; available in PMC: 2011 Nov 1.

Published in final edited form as: Int J Biol Macromol. 2010 Jul 14;47(4):471–482. doi: 10.1016/j.ijbiomac.2010.07.001

Table 3.

Inhibition constants of wild type CDA and of Y33G mutant enzyme


	Ki (10⁻⁵ M)

Inhibitors	wild-type CDA^a	Y33G
Uridine	40.0	2.12
6-[3,5(cytidyl)acryloylamino] hexanoic acid (CV6)^a	4.50	0.34
3,4,5,6-Tetrahydrouridine (THU)	0.67	2.56
5-Fluorozebularine	0.03	0.02

Inhibition constants were obtained from the double-reciprocal plots of the deamination of deoxycytidine in the presence and absence of the inhibitors. All the inhibitors were competitive.

^a)

[5].