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. 2010 Dec 1;29(23):3893–3895. doi: 10.1038/emboj.2010.281

Figure 1.

Figure 1

A simplified model of teratoma formation by HDAC1 wild-type and knockout ES cells. The EMT inducer SNAIL1 is a direct target of HDAC1. In HDAC1 wild-type teratomas, SNAIL1 expression is repressed while E-cadherin expression is activated. Epithelial structures are highly differentiated and correspond to the phenotype of benign and mature teratomas. In HDAC1 knockout teratomas, SNAIL1 expression is induced, and overexpression of HDAC2 cannot compensate for the loss of HDAC1. Although SNAIL1 is a repressor of E-cadherin, HDAC1 is also a crucial co-repressor of the E-cadherin promoter, so that in its absence, the promoter stays activated. It should be noted that this observed phenotype corresponds to malignant and immature teratocarcinomas.