Table III. The mice reconstituted with MLL–CBP (bromo + HAT) develop a preleukemic disease similar to that observed with full length MLL–CBP.

Experimenta	Construct	Linlo cells injected per mouse (×103)	Proportion of donor cellsb (%)	Myeloid/donorb (%)	Mean survival (range)
1 (n = 10)	MIE	15	25 ± 3	8 ± 1	>350 days
	MLL–CBP	16	64 ± 3	24 ± 3	164 days (126–188)
2 (n = 9)	MIE	12	15 ± 6	13 ± 2	>180 days
	MLL–CBP-bromo+HAT	12	43 ± 9	39 ± 8	NDc

^aThe number of mice reconstituted with each construct is shown in parentheses.

^bThe mice were bled at 7 weeks (experiment 1) or 11 weeks (experiment 2) post-reconstitution. The values shown are the mean ± SEM.

^cThree mice died of acute myeloid leukemia between 139 and 174 days after transplantation. Unfortunately, this cohort could not be studied further as the remaining mice succumbed to hyperthermia following an air conditioner failure.