TABLE 3.
Cell and Cell Derived Biomarkers
| Marker Type | H | ES | LT | P |
|---|---|---|---|---|
| CD133+ PC | 954 (712–157) | 1052 (538–1277) | 639 (448–1243) | 0.08 |
| CD34+ PC | 2676 (1763–4644) | 3432 (2153–4125) | 1818 (1341–3268) | 0.06 |
| CD133+ CD34+ PC | 778 (618–1251) | 868 (407–1228) | 605 (356–1208) | 0.15 |
| CD133+ VEGF-R2+ PAC |
8.6 (0–20) | 18.3 (0–21) | 0 (0–9)# | 0.04* |
| CD34+ VEGF-R2+ PAC |
15.3 (9–26) | 7.9 (6–40) | 8.0 (0–18) # | 0.03* |
| CD133+ CD34+ VEGF-R2+ PAC |
6.9 (0–12) | 0 (0–20) | 0 (0–7)‖ | 0.04* |
| CD144+ MPs | 204 (93–411) | 453 (187–616) | 571 (207–892)‖ | 0.03* |
| CD41+ MPs | 300 (155–583) | 693 (239–894) | 367 (258–939)‖ | 0.03* |
| CD14+ MPs | 120 (68–347) | 340 (178–469) | 230 (77–488) | 0.15 |
| AnnV+ MPs | 355 (240–760) | 761 (449–996)¶ | 682 (330–1044)‖ | 0.02* |
| nM of PS+ MPs | 0.31 (0.21–0.36) | 0.27 (0.16–0.40) | 0.45 (0.28–0.56)‖# | 0.02* |
Data are medians (25%–75% Interquartile Range). P(A)C values correspond to Cells/mL, MP values correspond to MPs/µL except PS+ MPs which corresponds to nM of PS equivalent by plate based assay. H indicates healthy; ES, early stage diabetes; LT, long term diabetes.
P<0.05
Post-hoc comparison significance levels (not adjusted for multiple comparisons)
P < 0.01 LT vs. H,
P <0.01 ES vs. H,
P < 0.01 LT vs. ES
P< 0.05 LT vs. H,
P < 0.05 ES vs. H,
P < 0.05 LT vs. ES
P calculated by JT test to test for differences between the three groups. Post-hoc analyses between patient groups used the two sample Wilcoxon test.