Fig. 1. Residues involved in NFAT1–Fos–Jun interaction. (A) Close-up view of the NFAT1–Fos–Jun–DNA complex (Chen et al., 1998). Ribbon diagram made using Rasmol. Side chains of NFAT1 involved in NFAT1–Fos, NFAT1–Jun and NFAT1–DNA interactions that were mutated in this study are shown. (B) Amino acid sequence and secondary structure of the NFAT1 DBD. Residues that contact Fos are shown in open boxes while residues involved in Jun contacts are shown in white inside black boxes. The residues mutated in this study are indicated by asterisks.