Table 1.

Accrual Status and Reasons for < 90% Accrued in CTEP-Sponsored Phase III Trials Activated From 2000 to 2007 (191 trials)

Status	No. of Trials
Accrual not over	58
≥ 90% accrued so far	9
< 90% accrued so far	49
Accrual over	133
≥ 90% accrued	68
< 90% accrued	65
Reasons for < 90% accrued
Interim monitoring	12*†
External information	9*
Drug supply issues	2
Unacceptable toxicity	3
Inadequate accrual rate	41

Abbreviation: CTEP, Cancer Therapy Evaluation Program.

^*Includes two trials that had < 90% accrued because of both interim monitoring and external information.

^†Two of the 12 trials were stopped for superiority monitoring; the other 10 were stopped for futility monitoring.