Table 2.
Patient | Age (years) | Sex | KPS | MGMT Methylation | Humoral Response |
DTH Response |
PFS (months) | OS (months) | ||
---|---|---|---|---|---|---|---|---|---|---|
Before Vaccination | After Vaccination | Before Vaccination | After Vaccination | |||||||
1 | 62 | M | 90 | ME | N/A | N/A | — | — | 6.7 | 16.2 |
2 | 49 | M | 80 | N/A | N/A | N/A | — | — | 6.4 | 18.0 |
3 | 51 | M | 100 | N/A | N/A | N/A | — | — | 9.9 | 21.0 |
4 | 48 | M | 100 | U | — | +* | — | + | 58.5† | 58.5‡ |
5 | 52 | M | 100 | ME | — | — | — | — | 13.5 | 22.6 |
6 | 42 | M | 100 | U | — | — | — | + | 14.9 | 35.8 |
7 | 51 | M | 90 | U | — | — | — | + | 54.6† | 54.6‡ |
8 | 33 | M | 100 | N/A | — | — | — | — | 53.7† | 53.7‡ |
9 | 46 | F | 90 | ME | — | — | — | — | 15.4 | 34.9 |
10 | 29 | M | 90 | N/A | — | — | — | N/A | 6.4 | 11.2 |
11 | 64 | M | 90 | U | N/A | N/A | — | — | 12.0 | 21.6 |
12 | 64 | M | 80 | U | — | + | — | — | 27.6 | 44.1 |
13 | 54 | F | 90 | N/A | — | — | — | — | 17.6 | 26.0 |
14 | 63 | M | 80 | ME | — | + | — | — | 10.9 | 20.8 |
15 | 67 | F | 80 | ME | — | + | — | — | 6.5 | 13.4 |
16 | 53 | F | 100 | ME | — | + | — | — | 30.0 | 47.7 |
17 | 52 | M | 100 | ME | — | + | — | — | 5.4 | 47.4‡ |
18 | 64 | F | 90 | U | — | — | — | — | 16.4 | 23.1 |
Abbreviations: KPS, Karnofsky performance status; MGMT, methylguanine methyltransferase; DTH, delayed-type hypersensitivity; PFS, progression-free survival; OS, overall survival; M, male; ME, methylated; N/A, sample not available; U, unmethylated; F, female; (—), no response; (+), positive response.
Positive humoral response in CSF.
No progression.
Alive.