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. 2010 Nov 8;286(2):1014–1024. doi: 10.1074/jbc.M110.149062

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Effects of siARNT1 and siARNT2 siRNA duplexes on gene expression, protein levels, and insulin secretion in 832/13 cells. A, both siARNT1 and siARNT2 decrease ARNT/HIF-1β mRNA levels in 832/13 cells. B and C, immunoblot analysis of extracts from 832/13 cells treated with siControl (siCon) and siARNT1. D, siARNT1 and siARNT2 inhibit glucose-stimulated insulin secretion in 832/13 cells. Results represent mean ± S.E. of 3–6 independent experiments. LG, low glucose (2 mm); HG, high glucose (16.7 mm). A and B, ***, p < 0.001; **, p < 0.01l; siControl versus siARNT. D, **, p < 0.01; *, p < 0.05; high glucose siControl versus high glucose siARNT.