FIGURE 3.
ATP released via Cx30 acts in a paracrine manner to regulate ENaC. Summary graphs of ENaC open probability (A; Po), ENaC membrane levels (B; fN), and ENaC activity (C; fNPo) for wild-type (black bars; n = 29, 20 & 18 and 83, 46 & 63, respectively, for A & B) and Cx30−/− (gray bars; n = 23, 24 & 31 and 36, 51 & 78, respectively for A & B) mice maintained for a week on low, regular, and high [Na+] diets. *, significant (p < 0.05) decrease versus <0.01% [Na+] diet; **, significant (p < 0.05) increase versus wt on the same diet.