FIGURE 1.

Alternation of BH4 and monoamine contents in the brains of wild-type and Spr mutant mice in the early postnatal period. Contents of BH4 (A), dopamine (B), homovanillic acid (HVA, C), serotonin (D), and 5-hydroxyindoleacetic acid (5HIAA, E) in whole brain homogenates were measured by HPLC with fluorescence (A) or electrochemical (B–E) detection. The values represent the mean ± S.E. n = 4 mice for all groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001, one-way ANOVA followed by Tukey's test. Stars over bars indicate difference between wild-type and Spr^−/− mice within the same age, and stars above lines indicate difference between wild-type mice of different ages.