FIGURE 2.

Alternation of biopterin and monoamine contents in the brains of wild-type and Pts mutant mice in the early postnatal period. Contents of total biopterin (A), dopamine (B), homovanillic acid (HVA, C), serotonin (D), and 5-hydroxyindoleacetic acid (5HIAA, E) in whole brain homogenates were measured by HPLC with fluorescence (A) or electrochemical (B–E) detection. Values represent the mean ± S.E. n = 3 mice for all groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001, one-way ANOVA followed by Tukey's test. Stars over bars indicate differences between wild-type and Pts mutant mice within the same age, and stars above lines indicate differences between DPS-Pts^−/− and Pts^−/− mice or between wild-type or DPS-Pts^−/− mice of different ages.