FIGURE 6.

Hind-limb clasping in a tail suspension test. P14 mice were suspended by the tail for 25 s, and the duration of hind-limb clasping was measured. A and B, representative clasping observed in Spr^−/− mice (B) but not in Spr^+/+ mice (A) is shown. C, summary of total duration of hind-limb clasping during a 25-s trial in Spr^+/+ (n = 12), Spr^+/− (n = 13), and Spr^−/− (n = 14) mice is shown. Values indicate the mean ± S.E. ***, p < 0.001, Kruskal-Wallis nonparametric one-way ANOVA followed by Steel-Dwass test. Stars over bars indicate differences between Spr^−/− mice and wild-type mice.