TABLE 2.

Activation and deactivation kinetics of hKv7.4/mt channels

Data for the individual activation and deactivation time constants from CHO cells expressing of wild type and each mutant with 1:1 ratio were obtained from five to seven cells. All values are mean ± S.D. (*, p < 0.05, **, p < 0.01).

	τactivation (40 mV)		τdeactivation (−40 mV), τ (ms)
	τfast (ms)	τslow (ms)
WT	107 ± 14	698 ± 71	178 ± 38
F182L	83 ± 21*	587 ± 90*	111 ± 48
WT:F182L	91 ± 19*	496 ± 81**	137 ± 16*
WT:L274H	114 ± 16	683 ± 28	158 ± 15
WT:W276S	174 ± 40**	629 ± 40*	142 ± 15
WT:L281S	87 ± 13**	466 ± 79**	110 ± 49
WT:G285S	85 ± 26	488 ± 87**	129 ± 28*
WT:G296S	75 ± 18**	458 ± 85**	121 ± 37*
WT:G321S	64 ± 14**	591 ± 81*	149 ± 32