TABLE 1.
Physiological and echocardiographic indices in 2- and 8-month-old taz-deficient (tazdef) and NTG mice
All values are mean ± S.E. Significant differences between NTG and taz-deficient groups are indicated. Hw/Bw, heart weight (milligrams)/body weight (grams) ratio; HR, heart rate (beats/min (bpm)); IVSd, diastolic interventricular septal wall thickness; LVPWd, diastolic left ventricular posterior wall thickness; LVIDd, diastolic left ventricular internal dimension; LVIDs, systolic left ventricular internal dimension; LV Vold, left ventricular diastolic volume; LV Vols, left ventricular systolic volume; FS, left ventricular fractional shortening; EF, left ventricular ejection fraction.
| Variable | 2 months |
8 months |
||
|---|---|---|---|---|
| NTG (n = 6) | tazdef (n = 4) | NTG (n = 4) | tazdef (n = 4) | |
| Body weight (g) | 22.7 ± 0.737 | 22.2 ± 0.5 | 38.6 ± 2.3 | 32.2 ± 1.7a |
| Hw/Bw (mg/g) | 5.0 ± 0.2 | 5.2 ± 0.7 | 3.9 ± 0.1 | 4.3 ± 0.3a |
| HRb (bpm) | 442 ± 10 | 383 ± 38 | 450 ± 13 | 460 ± 30 |
| IVSd (mm) | 0.65 ± 0.03 | 0.71 ± 0.04 | 0.68 ± 0.03 | 0.50 ± 0.07c |
| LVPWd (mm) | 0.55 ± 0.04 | 0.68 ± 0.03a | 0.60 ± 0.02 | 0.41 ± 0.06c |
| LVIDd (mm) | 4.24 ± 0.13 | 4.13 ± 0.20 | 4.63 ± 0.19 | 4.98 ± 0.10 |
| LVIDs (mm) | 3.08 ± 0.02 | 2.88 ± 0.20 | 2.92 ± 0.16 | 3.80 ± 0.07c |
| LV Vold (μl) | 80.9 ± 5.8 | 77.0 ± 8.6 | 88.2 ± 6.9 | 117.1 ± 5.4c |
| LV Vols (μl) | 38.1 ± 4.8 | 32.9 ± 5.5 | 36.8 ± 3.7 | 61.8 ± 2.6c |
| FS (%) | 28 ± 2 | 31 ± 2 | 31 ± 2 | 24 ± 1c |
| EF (%) | 54 ± 4 | 58 ± 3 | 58 ± 2 | 47 ± 1c |
| LV walld (μl) | 74.1 ± 5.2 | 83.7 ± 8.4 | 85.1 ± 1.2 | 74.6 ± 2.3a |
a p < 0.05.
b Anesthetized heart rate.
c p < 0.001.
d Left ventricular volume determined by cardiac MRI.