mRNA expression of LOXL2 is highly increased compared with LOX and other isoforms in differentiating ATDC5 cell line. Quantitative real-time PCR analyses of LOX, LOXL1, 2, 3, and 4, in differentiating ATDC5 cells. RNA was extracted at different time points. The mRNA expression relative to GAPDH was determined and the fold changes were calculated relative to day 0 (*, p < 0.05; ANOVA; n = 3).