TABLE 1.
Baseline characteristics of the study population
| Characteristic | No. (%) of patientsa |
P value | ||
|---|---|---|---|---|
| Total | Naïve | Treatment experienced | ||
| No. of samples | 145 | 65 | 80 | |
| Median age in years (range) | 39.2 (22-75) | 37.4 (22-71) | 41.7 (22-75) | 0.177 |
| Female | 35 (24.1) | 14 (21.5) | 21 (26.3) | 0.510 |
| Transmission route | 0.010 | |||
| Intravenous drug use | 55 (37.9) | 15 (23.1) | 40 (50.0) | |
| Male homosexual activity | 41 (28.3) | 26 (40.0) | 15 (18.8) | |
| Heterosexual activity | 40 (27.6) | 19 (29.2) | 21 (26.3) | |
| Other | 4 (2.8) | 2 (3.1) | 2 (2.5) | |
| Not known | 5 (3.4) | 3 (4.6) | 2 (2.5) | |
| Median no. of years from HIV infection diagnosis (range) | 5.88 (0-26.3) | 0.63 (0-23.8) | 11.5 (0.2-26.3) | <0.001 |
| Median no. of CD4 cells/mm3 (range) | 300 (0-820) | 375 (10-820) | 270 (0-786) | 0.027 |
| Median HIV-1 RNA load, log10 copies/ml (range) | 4.5 (1.5-7.0) | 4.7 (2.0-6.9) | 4.0 (1.5-7.0) | <0.001 |
| CDC stage | <0.001 | |||
| A | 82 (56.6) | 55 (84.6) | 27 (33.8) | |
| B | 18 (12.4) | 3 (4.6) | 15 (18.8) | |
| C | 45 (31.1) | 7 (10.8) | 38 (47.6) | |
| Hepatitis C virus coinfection | 56 (39.2) | 17 (26.2) | 39 (48.8) | 0.004 |
| HIV-1 subtypeb | 0.035 | |||
| B | 125 (86.2) | 57 (87.5) | 68 (85) | |
| Other | 6 (4.1) | 5 (7.7) | 1 (1.3) | |
| Not tested | 14 (9.7) | 3 (4.6) | 11 (13.8) | |
a
Values represent the numbers and percentages of patients exhibiting each characteristic unless otherwise noted in the first column.
b
Subtype of the V3 loop predicted by the Geno2pheno (coreceptor) bioinformatic tool.