Table 3.
Haplotype analyses for Lp(a) and CAAD.
| Trait | SNPs | High risk haplotypes(s)* | Frequency | Lp(a) β or CAAD OR | P-value (Lp(a) % variance)† |
|---|---|---|---|---|---|
| Lp(a) | rs3798221/rs10455872 | GA | 0.017 | 1.8 | 1.3 × 10−76 (21%) |
| AG | 0.076 | 1.8 | |||
| Lp(a) | rs6919346/rs3798221/rs10455872 | GGA | 0.017 | 2.1 | 5.0 × 10−82 (23%) |
| GAG | 0.075 | 2.1 | |||
| GAA | 0.75 | 0.42 | |||
| Lp(a) | rs6919346/rs3798220/rs10455872/rs2295368‡ | GAAA | 0.34 | 0.62 | 4.1 × 10−12 (25%) |
| Lp(a) | rs6919346/rs3798220/rs3798221/rs10455872/rs2295368‡ | GACAA | 0.27 | 0.94 | 8.3 × 10−18 (25%) |
| CAAD | rs6919346/rs10455872 | GG | 0.075 | 2.0 | 0.020 |
| CAAD | rs3123629/rs6919346/rs10455872 | AGG | 0.066 | 2.1 | 0.054 |
Haplotype analyses were performed using covariates as described in Methods.
*
Haplotypes among the set tested with the largest β for Lp(a) or OR for CAAD.
†
P-values are for the global test of no difference between haplotypes versus any differences and are Bonferroni corrected for the number of haplotypes tested.
‡
Conditional on the major allele (AA) background of rs3798220 and rs10455872.