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. 2011 Jan 13;7(1):e1001273. doi: 10.1371/journal.pgen.1001273

Table 1. RA and CD candidate genes are preferentially expressed in immune tissues.

Rheumatoid arthritis Crohn's disease
Tissue p-value Tissue p-value
TonsilsCD4posTcells 1.21E-06 Tcellseffectormemory 0.010879534
Th1 3.60E-06 TcellsBAFFpos 0.021533643
TcellsCD57pos 5.74E-06 Treg 0.040222981
Treg 2.42E-05 Tcellscentralmemory 0.047167636
Lymphnode 4.58E-05 ThymicSPCD8posTcells 0.052512983
Th2 5.42E-05 PeripheralnaiveCD4posTcells 0.062360126
TcellsBAFFpos 0.00012286 ThymicSPCD4posTcells 0.063736236
PeripheralCD8posTcells 0.000416196 MacrophageLPS4h 0.067420383
Tcellscentralmemory 0.000547856 MyeloidCD33pos 0.082208219
Tcellseffectormemory 0.000896003 PeripheralCD8posTcells 0.083132825
Tonsils 0.003590718 DC 0.090095533
ThymicSPCD8posTcells 0.005276588
ThymicSPCD4posTcells 0.010418466
PeripheralnaiveCD4posTcells 0.011665294
NKCD56pos 0.017592624
Tcellsgammadelta 0.018660953
MacrophageLPS4h 0.029525421
DC 0.046402891
Spleen 0.048696618
DCLPS48h 0.063014104
ThymicCD4posCD8posCD3pos 0.091299315

Expression data was downloaded from a publically available dataset [46]. The data had been previously converted into enrichment scores (see Materials and Methods). The enrichment scores of candidate genes in RA and CD were compared to the rest of the genome by a one-tailed rank-sum test. The tissues that received a p-value of <0.1 are shown. Of note, all tissues in this category for both RA and CD are immune, as shown in Figure 3.