Figure 8. Simulations of viral genomic diversification with a multiplicative fitness landscape and comparisons with patient data.

The evolution of viral diversity, d_G, with generations predicted by our simulations (lines) for different population sizes C = 200 (solid) and 10000 (dashed) with a multiplicative fitness landscape (see text) with s = 0.01 (pink) and 0.001 (cyan). Each cell is assumed to be infected with M virions drawn from a distribution based on a viral dynamics model (see text). Different symbols are data from nine different patients [36] shown also in Figs. 3 and 7.