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. 2011 Jan 13;6(1):e16078. doi: 10.1371/journal.pone.0016078

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Secondini et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Number of osteoclasts (N.Oc/BS; /mm, +/− SD) on the endosteal surface in trabecular and cortical bone of sham-operated tibiae or on residual bone adjacent to cancer cells of tibiae xenografted with PC-3/Fluc, mock and Nog-KD clones. n = 6–7 animals for each experimental group. ***P<0.001, PC-3/Fluc and mock clones versus sham, and mock clones versus Nog-KD 17; **P<0.01, Nog-KD 17 versus PC-3/Fluc, and Nog-KD 14 versus PC-3/Fluc and mock clones. B. Number of osteoblasts (N.Ob/BS; /mm, +/− SD) on the endosteal surface in trabecular and cortical bone of sham-operated tibiae or on residual bone adjacent to cancer cells of tibiae xenografted with PC-3/Fluc, mock and Nog-KD clones. n = 6–7 animals for each experimental group. ***P<0.001, PC-3/Fluc and mock clones versus Nog-KD clones, and mock 4 versus sham; **P<0.01, sham versus PC-3/Fluc and mock 5; *P<0.05, Nog-KD 14 versus sham. C. Percentage of endosteal surface in cortical and trabecular bone occupied by osteoclasts (Oc.S/BS; %, +/− SD) in sham-operated and cancer cell-xenografted tibiae. n = 6–7 animals for each experimental group. ***P<0.001, mock clones versus sham and Nog-KD clones, and PC-3/Fluc versus sham and Nog-KD 17; **P<0.01, Nog-KD 14 versus PC-3/Fluc. D. Percentage of endosteal surface in cortical and trabecular bone occupied by osteoblasts (Ob.S/BS; %, +/− SD) in sham-operated and cancer cell-xenografted tibiae. n = 6–7 animals for each experimental group. ***P<0.001, PC-3/Fluc and mock clones versus sham and Nog-KD clones.