Table 1.
Exposure | Treatment | # Mice | # Died(%) | Bleeding (#)a | |||
---|---|---|---|---|---|---|---|
Vaginal | Orbital | Tail | Gastrointestinal | ||||
GD 8–12 | control | 26 | 0 | 0 | 0 | 0 | 0 |
cyn | 42 | 23(55)b,c,d | 13 | 2 | 2 | 0 | |
GD 13–17 | control | 26 | 0 | 0 | 0 | 0 | 0 |
cyn | 42 | 0 | 0 | 1 | 0 | 3e |
Multiple effects occurred in single animals
p<0.01
Includes 8 animals killed when moribund (GD13)
5 (GD12); 8 (GD13); 1 (GD16); 1 (GD18)
2 instances of intestinal bleeding were noted in the 4 animals killed on GD 13 and 1 instance was seen 7 days post dosing