Table 2.
Clinical chemistries and organ/body weight ratios for GD8–12 animals
| Days after | No. | Kill Wt | L/BW | K/BW | AAT* | ALP | ALT | AST | LDH | SDH | BUN | Creatinine | Glucose | Albumin | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| last dose | mg/dL | IU/L | IU/L | IU/L | IU/L | IU/L | mg/dL | mg/dL | mg/dL | g/dL | |||||
| 1 | Con | 3 | 40.2±1.5 | 6.2±0.2 | 1.1±0.1 | 10.3±0.6 | 50.3±2.0 | 30.6±2.3 | 82.1±4.8 | 378.5±22.4 | 39.9±3.4 | 12.1±1.2 | 0.35±0.01 | 150.9±15.4 | 2.2±0.0 |
| %cv | 6.5 | 6.6 | 9.6 | 9.8 | 6.8 | 12.8 | 10.2 | 10.3 | 14.6 | 16.7 | 6.61 | 17.7 | 0.6 | ||
| Cyn | 5** | 32.21;±2.1 | 6.5±0.5 | 1.2±0.1 | 34.11±16.9 | 59.1±4.1 | 112.11 ±37.01> | 219.31;±35.91 | 692.2±361.81 | 50.5±7.71 | 129.31±30.91 | 0.602±0.131 | 130.2±11.4 | 0.91±0.2 | |
| %cv | 14.4 | 15.8 | 22.0 | 70.1 | 14.0 | 65.4 | 40.6 | 98.7 | 40.9 | 50.6 | 64.60 | 21.5 | 46.1 | ||
| 7 | Con | 3 | 36.0±2.4 | 6.0±0.6 | 1.3±0.1 | 9.8±0.1 | 52.0±8.8 | 37.8±6.0 | 65.7±1.8 | 255.2±43.7 | 32.1±3.8 | 17.8±0.7 | 0.45±0.04 | 218.2±31.7 | 3.4±0.3 |
| %cv | 11.6 | 17.1 | 3.3 | 1.9 | 28.9 | 27.3 | 4.8 | 29.6 | 20.7 | 6.5 | 14.64 | 25.1 | 14.3 | ||
| Cyn | 5 | 34.9±1.7 | 6.3±0.6 | 1.2±0.1 | 10.0±0.5 | 64.3±10.4 | 38.2±0.4 | 65.2±3.2 | 227.1±16.8 | 33.7±3.5 | 15.4±2.5 | 0.39±0.02 | 204.1±22.8 | 3.1±0.1 | |
| %cv | 10.7 | 21.1 | 8.9 | 10.7 | 36.0 | 22.3 | 11.1 | 16.5 | 23.3 | 36.6 | 8.87 | 25.0 | 7.7 | ||
| 14 | Con | 3 | 34.4±1.7 | 5.6±0.1 | 1.2±0.1 | 9.9±0.2 | 93.9±6.5 | 47.3±6.3 | 73.7±8.8 | 309.9±27.6 | 41.8±1.7 | 17.8±1.4 | 0.54±0.05 | 259.5±11.3 | 3.4±0.1 |
| %cv | 8.7 | 3.5 | 5.2 | 3.3 | 11.9 | 23.0 | 20.7 | 15.4 | 7.2 | 13.3 | 17.13 | 7.5 | 7.5 | ||
| Cyn | 3 | 34.6±0.2 | 6.1±0.5 | 1.3±0.1 | 9.1±1.1 | 80.0±7.3 | 48.3±3.0 | 125.5±13.1 | 451.9±51.3 | 57.1±7.2 | 20.9±2.0 | 0.43±0.05 | 207.9±13.3 | 3.4±0.1 | |
| %cv | 1.2 | 13.8 | 7.8 | 21.3 | 15.8 | 6.6 | 18.0 | 19.7 | 21.9 | 16.7 | 19.55 | 11.1 | 5.6 | ||
| 28 | Con | 3 | 36.8±2.0 | 5.2±0.4 | 1.0±0.1 | 10.5±0.9 | 85.2±6.6 | 46.3±5.4 | 65.9±4.6 | 290.0±91.9 | 35.7±8.9 | 20.6±5.3 | 0.39±0.02 | 281.3±1.8 | 3.0±0.1 |
| %cv | 9.4 | 13.8 | 1.3 | 14.9 | 13.5 | 20.3 | 12.0 | 54.9 | 43.1 | 44.2 | 7.71 | 1.1 | 7.0 | ||
| Cyn | 3 | 37.6±0.6 | 5.4±0.4 | 1.2±0.1 | 9.8±0.6 | 57.0±5.1 | 38.8±9.2 | 32.2±18.6 | 247.6±65.4 | 35.2±8.0 | 16.6±4.4 | 0.37±0.01 | 244.9±13.5 | 3.1±0.2 | |
| %cv | 2.1 | 11.4 | 4.7 | 10.1 | 15.5 | 41.2 | 68.4 | 45.7 | 39.4 | 45.9 | 6.80 | 9.6 | 10.6 | ||
| 42 | Con | 3 | 38.2±2.3 | 4.7±0.1 | 1.2±0.1 | 10.4±0.3 | 55.2±3.9 | 45.1±7.4 | 81.3±7.4 | 296.2±5.5 | 36.8±0.6 | 22.1±0.1 | 0.40±0.00 | 278.3±24.6 | 3.1±0.1 |
| %cv | 10.5 | 2.1 | 13.3 | 4.6 | 12.3 | 28.4 | 15.8 | 3.2 | 2.7 | 0.4 | 1.82 | 15.3 | 4.7 | ||
| Cyn | 3 | 36.0±0.8 | 5.0±0.1 | 1.1±0.1 | 10.2±0.2 | 72.6±7.7 | 42.9±5.7 | 65.6±6.4 | 207.1±6.3 | 30.8±3.8 | 19.6±0.6 | 0.40±0.00 | 247.7±3.3 | 3.1±0.1 | |
| %cv | 3.9 | 4.9 | 15.1 | 3.8 | 18.3 | 23.1 | 16.9 | 5.3 | 21.5 | 4.9 | 11.38 | 2.3 | 4.7 |
%cv = % coefficient of variation
1
= p<0.01
2
= p<0.05
Note that significances are given for both means and variance
*
AAT = antitrypsin; ALP = alkaline phosphatase; ALT = alanine aminotransferase; AST = aspartate aminotransferase; LDH = lactate dehydrogenase; SDH = sorbitol dehydrogenase; L/BW = liver/body weight ratio; BUN = blood urea nitrogen; K/BW = kidney/body weight ratio
**
AAT - 2 samples; LDH, BUN - 4 samples