Table 3.
Clinical chemistries and organ/body weight ratios for GD13–17 animals
| Days after | No. | Kill Wt | L/BW | K/BW | AAT* | ALP | ALT | AST | LDH | SDH | BUN | Creatinine | Glucose | Albumin | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| last dose | mg/dL | IU/L | IU/L | IU/L | IU/L | IU/L | mg/dL | mg/dL | mg/dL | g/dL | |||||
| 1 | Con | 2 | 30.1±3.0 | 6.6±0.6 | 1.3±0.1 | 9.2±0.1 | 56.5±2.7 | 42.3±4.9 | 57.4±3.9 | 277.1±49.3 | 33.3±8.2 | 26.2±0.1 | 0.45±0.02 | 210.7±9.7 | 3.6±0.7 |
| %cv | 14.1 | 13.5 | 15.9 | 2.1 | 6.8 | 16.2 | 9.7 | 25.1 | 35.1 | 0.8 | 5.03 | 6.5 | 26.8 | ||
| Cyn | 4 | 31.5±2.7 | 7.5±0.9 | 1.2±0.2 | 28.51±5.51 | 77.7±13.4 | 325.21±191.21 | 314.11±90.61 | 992.11±232.91 | 119.01±41.91 | 33.9±6.21 | 0.46±0.04 | 97.21±11.9 | 1.71±0.41 | |
| %cv | 17.2 | 24.6 | 26.3 | 38.3 | 34.5 | 117.6 | 57.7 | 46.9 | 70.3 | 36.3 | 17.68 | 24.5 | 52.3 | ||
| 7 | Con | 3 | 30.3±1.3 | 5.6±0.3 | 1.3±0.1 | 10.7±0.1 | 86.6±5.4 | 46.8±2.0 | 80.1±17.0 | 243.6±75.1 | 30.9±8.2 | 17.4±1.0 | 0.42±0.03 | 240.3±41.4 | 3.5±0.2 |
| %cv | 7.6 | 9.3 | 15.8 | 0.5 | 10.8 | 7.4 | 36.8 | 53.4 | 46.0 | 10.2 | 9.97 | 22.6 | 6.4 | ||
| Cyn | 5 | 32.1±1.5 | 8.5±0.61 | 1.4±0.1 | 12.2±1.3 | 82.9±6.1 | 74.7±31.6 | 70.2±8.3 | 340.9±74.4 | 44.5±8.7 | 19.1±3.2 | 0.41±0.02 | 214.1±5.0 | 3.2±0.2 | |
| %cv | 10.4 | 17.0 | 6.4 | 24.6 | 16.4 | 94.8 | 26.6 | 48.8 | 44.1 | 37.4 | 11.06 | 5.2 | 6.6 | ||
| 14 | Con | 3 | 33.1±1.0 | 4.9±0.2 | 1.4±0.1 | 9.7 | 92.7±10.8 | 41.6±2.1 | 60.4±1.1 | 233.7±31.7 | 36.5±8.4 | 12.7±1.7 | 0.45±0.05 | 324.6±36.5 | 2.9±0.2 |
| %cv | 5.5 | 8.5 | 5.1 | nd | 20.2 | 8.8 | 3.0 | 23.5 | 40.0 | 23.2 | 17.32 | 19.5 | 9.5 | ||
| Cyn | 5 | 31.9±0.6 | 5.7±0.3 | 1.3±0.1 | 9.6±0.2 | 76.6±8.4 | 40.6±2.2 | 64.1±5.0 | 294.2±38.8 | 34.2±4.9 | 14.8±1.4 | 0.45±0.03 | 277.2±16.5 | 3.5±0.1 | |
| %cv | 4.0 | 12.5 | 8.0 | 5.0 | 24.6 | 11.9 | 17.6 | 29.5 | 31.9 | 21.1 | 15.73 | 13.3 | 2.9 | ||
| 35 | Con | 2 | 34.2±1.3 | 4.5±0.3 | 1.2±0.1 | 9.9±0.2 | 82.8±7.2 | 49.4±9.2 | 73.1±9.5 | 271.8±38.8 | 36.1±3.4 | 21.1±4.5 | 0.42±0.01 | 327.6±79.9 | 3.1±0.1 |
| %cv | 5.4 | 9.5 | 9.7 | 3.4 | 12.3 | 26.3 | 18.3 | 20.2 | 13.4 | 29.9 | 4.04 | 34.5 | 3.9 | ||
| Cyn | 4 | 33.1±1.6 | 5.0±0.2 | 1.2±0.1 | 10.0±0.3 | 73.7±8.8 | 46.0±6.0 | 63.7±2.2 | 247.5±39.3 | 32.6±2.5 | 12.7±1.1 | 0.41±0.02 | 312.5±17.6 | 3.2±0.1 | |
| %cv | 9.9 | 9.2 | 3.7 | 5.6 | 24.0 | 26.3 | 7.0 | 31.7 | 15.1 | 17.1 | 7.93 | 11.3 | 2.9 | ||
| 49 | Con | 3 | 38.2±1.0 | 3.9±0.1 | 1.0±0.1 | 8.9±0.7 | 73.5±6.2 | 42.0±5.2 | 61.7±2.9 | 243.0±28.5 | 35.1±3.9 | 21.6±2.2 | 0.40±0.05 | 235.9±12.6 | 3.1±0.1 |
| %cv | 4.3 | 1.7 | 5.4 | 14.5 | 14.6 | 21.6 | 8.2 | 20.3 | 19.4 | 17.5 | 23.62 | 9.2 | 4.6 | ||
| Cyn | 5 | 33.1±0.92 | 4.6±0.2 | 1.3±0.1 | 10.0±0.2 | 65.6±1.5 | 35.3±2.5 | 57.2±3.9 | 183.7±17.7 | 27.6±1.7 | 15.4±0.7 | 0.42±0.02 | 263.2±21.6 | 3.1±0.1 | |
| %cv | 5.9 | 12.0 | 66.0 | 5.4 | 5.2 | 16.1 | 15.3 | 21.5 | 13.7 | 10.7 | 8.37 | 18.3 | 5.5 |
%cv = % coefficient of variation
1
= p<0.01
2
= p<0.05
Note that significances are given for both means and variance
*
AAT = antitrypsin; ALP = alkaline phosphatase; ALT = alanine aminotransferase; AST = aspartate aminotransferase; LDH = lactate dehydrogenase; SDH = sorbitol dehydrogenase; L/BW = liver/body weight ratio; BUN = blood urea nitrogen; K/BW = kidney/body weight ratio