Fig. 3.

Intravital microscopy data and compartmental analysis. (A) Vasculature highlighted with rhodamine B labeled dextran prior to injection of RBCMs. (B) Dylight 680 labeled 1% cross-linked RBCMs flowing through this stretch of vasculature 20 min after dosing, with ROI outlined in yellow. (C) Colored overlay of A and B, with dextran in blue and particles shown in red. Scale bars are 100 μm. (D) Two-compartment model schematic and governing equations used to fit the data. (E) Decrease in fluorescent signal in the ROI for the 2-h scan in this mouse. The semilog plot shows calculated fit for the two-compartment pharmacokinetic models.