Fig. 1.

Ablation of Rarb results in a delay of gland duct development and changes in the stromal transcriptome. (A) Mammary whole-mount staining showed that ablation of Rarb results in a delay of mammary tree development in 40-d-old Rarb^−/− mice compared with their wild-type siblings. LN, lymph node; MG3 and MG4, mammary glands 3 and 4; TEB, terminal end bud. (Scale bars: 500 μm.) (B) Quantification of the distance between the terminal end buds and the lymph node in wild-type and Rarb^−/− mammary gland 4. *P < 0.001. (C) Intracellular localization of genes known to be associated with the cancer phenotype and differentially expressed in Rarb-null stroma. Red, up-regulated genes; green down-regulated genes.