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Ablation of Rarb suppresses ErbB2-induced mammary tumorigenesis. (A) Rarb−/− mice are resistant to mammary tumors induced by activated ErbB2 when expressed from its own promoter (n = 23 Rarb−/− and 42 wild-type mice). (B) Rarb−/− mice show a significant delay (P < 0.001 log-rank test) in tumor formation when the expression of ErbB2 is driven by the MMTV-LTR promoter (n = 30 Rarb−/− and 27 wild-type mice).
