Table 1.

Compound sets that best discriminate between HNF4α mutant vs. wild-type LCLs, based on a cellular ATP assay and compound set enrichment analysis

Compound set	NES	P value	Representative compound	Interaction in β-cells
Linoleic acid	−1.73	6.1 × 10-3	linoleic acid	+
ω-6 fatty acids	−1.61	0.03	linoleic acid	+
Oxicam antiinflammatories	−1.48	0.026	meloxicam	−
Class Ic antiarrhythmics	−1.34	0.12	propafenone	+
Coxib antiinflammatories	1.44	0.035	rofecoxib	−
Potassium-sparing diuretics	1.52	0.015	amiloride	+
Acetic acid antiinflammatories	1.53	0.026	diclofenac	−
HMG CoA-reductase inhibitors	1.53	7.9 × 10-3	simvastatin	+
Imidazole/triazole antiinfectives	1.55	0.056	fluconazole	−
Glucocorticoids	1.69	0.028	dexamethasone	−

Compound sets shown had the lowest permutation P values of all the compound sets tested (Table S2). Representative compounds from each set were tested for their ability to also discriminate between control- and HNF4α-knockdown β-cells (last column and Fig. 5)