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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Genet Epidemiol. 2010 Dec;34(8):792–802. doi: 10.1002/gepi.20523

TABLE IV.

Standard errors (SE) of risk parameters for the proposed approach

Parameter True
value		 SE of parameter
estimates		 Mean
estimated SE		 True SE
β X 1.099 0.308* 0.284 0.293
β A1 0.693 0.073 0.092 0.092
β AX1 0.693 0.266* 0.255 0.252
β A2 0.000 0.076 0.081 0.082
β AX2 0.693 0.308* 0.278 0.278

Genotype is simulated at the two marker loci with PMi = 0.25, i = 1,2. The environmental covariate (X) is Normal (0, 0.1). The measurement error is additive with variance of noise that is 0.25.

*

The data are simulated and analyzed under the additive effect model. 5%-trimmed values are marked by *. The results are based on 500 samples of 1,000 cases and 1,000 controls.