Table 1.

Snail can regulate oxidative stress-responsive genes. Total cellular RNA isolated from ARCaP-Neo or ARCaP-Snail cells was reverse-transcribed and real time PCR performed utilizing PCR Array profiles expressing 84 genes related to oxidative stress. Raw Ct values for individual genes were converted to fold change results (ARCaP-Snail:ARCaP-Neo) using RT² PCR Array Data Analysis portal (http://www.SABiosciences.com/pcrarraydataanalysis.php) and GAPDH as the endogenous control gene.

Gene Symbol	Gene Name	Fold Up- oi Down- regulation	Pathway/ Gene Function
PXDN	Peroxidasin	353.29	catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine, extracellular matrix formation (Nelson et al, 1994)
AOX1	Aldehyde Oxidase 1	14.56	produces ROS (Neumeier et al, 2006)
SEPP1	Selenoprotein P. plasma, 1	8.54	Oxidative stress responsive gene (Burk & Hill, 2005)
PDLIM1	PDZ and LIM domain 1	6.08	actin stress fiber formation (Tamura et al, 2007)
CYGB	Cytoglobin	3.27	scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Halligan et al, 2009)
PNKP	Polynucleotide kinase-3′- phosphatase	2.84	Oxidative stress responsive gene (Jilani et al, 1999)
SRXN1	Sulfiredoxin 1 homolog	2.7	Oxidative stress responsive gene (Rhee et al, 2007)
PTGS2	Prostaglandin-endoperoxide synthase 2	−5.24	key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase (Otto & Smith, 1995)
NOS2	Nitric oxide synthase 2, inducible	−10.77	Induces Nitric oxide reactive free radical which acts as a biologic mediator in several processes (Hevel et al, 1991)