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Multitargeted compounds. Compounds are described in the text. (A to F) Dual inhibitors of DNA gyrase and topoisomerase II. (G) Inhibitor of DNA Pol IIIC and -E of Gram-positive organisms. (H and I) Inhibitors of β-keto-acyl-ATP synthases of FAS II. (J) Nitazoxanide, an inhibitor that inactivates a cofactor, thiamine triphosphate, of the enzyme pyruvate:ferredoxin oxidoreductases.
