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Spectra and target locations of antibacterials. Drugs in red are active against Gram-positive organisms only and have cytoplasmic targets. Drugs in black are broad-spectrum cytoplasmic agents. Drugs in blue act extracellularly. Only 4 classes are currently useful against P. aeruginosa, with 2 acting outside the CM (polymyxin B and the β-lactams) and 2 being cytoplasmic (aminoglycosides and the FQs).
