FIG. 6.

Schematic of P1 adhesin. The molecule is divided into domains I, II, and III, which are linked by predicted flexible hinges. Domain I is highly conserved. The TM segment is marked. The N-terminal 59 residues are removed during the maturation process at the position marked by an open triangle. The regions homologous to paralogs are indicated by lines marked RepMP4 and RepMP2/3. The binding sites of inhibitory antibodies, which should mark exposed regions, are indicated by filled triangles (8, 43, 46). Domain III is inside the cell and probably interacts with other proteins in the cell. Two molecules of P1 are predicted to fold into a globular complex with two molecules of P90.