Table 2.
Comparison of Genes Upregulated in Radio-Resistant Head and Neck Cancer Cells and in Fibroblasts That Overexpress Signal Transducers and Activators of Transcription 1
|
A. Genes differentially expressed in nu61 cells relative to SCC-61 cellsa | ||
|---|---|---|
| Symbol | N/S R, experiment 1 | N/S R, experiment 2 |
| OAS1b | 3.286 | 2.282 |
| OAS1b | 4.506 | 2.491 |
| OAS3b | 3.624 | 2.318 |
| BST2b | 10.343 | 5.196 |
| CXCL10 | 10.319 | 2.820 |
| CIorf29 | 33.479 | 45.942 |
| CCNA1 | 2.172 | 2.376 |
| FLJ20035b | 8.787 | 6.389 |
| FLJ20637 | 7.315 | 3.441 |
| IRF7b | 3.254 | 2.713 |
| G1P3 | 3.401 | 5.341 |
| G1P2b | 8.500 | 6.452 |
| IFI27b | 5.425 | 9.462 |
| IFI35b | 4.528 | 2.653 |
| IFI44b | 5.654 | 3.212 |
| IFI44b | 8.102 | 4.187 |
| IFIT4 | 6.479 | 2.781 |
| IFIT1b | 8.606 | 9.055 |
| MX1b | 6.204 | 6.327 |
| LAMP3 | 7.084 | 3.025 |
| MDAS | 2.617 | 2.761 |
| PLSCR1b | 3.498 | 2.428 |
| STATαb | 2.370 | 2.578 |
| STAT1βb | 4.094 | 2.272 |
| IFITM1b | 4.298 | 3.036 |
|
B. Genes induced by exogenous STAT1 overexpression in BJ cellsc | ||
|---|---|---|
| Gene symbol | WT | YF |
| IFI27b | 4.3 | 8.1 |
| BST2b | 3.7 | 8.1 |
| OAS1b | 3.1 | 6.3 |
| 5.1 | 6.9 | |
| OAS2 | 4.1 | 6.2 |
| OAS3b | 2.5 | 2.6 |
| STAT1b | 2.2 | 2.8 |
| 1.7 | 2.0 | |
| FI44b | 2.6 | 3.3 |
| IFI44L | 5.2 | 7.7 |
| IFIH1 | 2.7 | 4.0 |
| IFITM1b | 2.0 | 2.5 |
| IFI35b | 2.1 | 2.2 |
| IFIT3 | 2.9 | 2.4 |
| MX1b | 3.6 | 5.3 |
| IRF7b | 3.0 | 4.3 |
| G1P2b | 2.7 | 3.0 |
| IFIT1b | 2.3 | 2.9 |
| PLSCR1b | 2.4 | 3.2 |
| HERC6 | 3.4 | 3.7 |
| FLJ20035b | 2.1 | 2.9 |
| EPSTI1 | 2.5 | 3.4 |
a
Increased expression of 24 genes in radio-resistant head and neck cancer cells, compared to the parental cell line (Khodarev and others 2004). N/S R represents the ratios of expression of genes in nu61 cells relative to SCC-61 cells.
b
Genes found in common in the 2 independent studies.
c
Genes induced by exogenous overexpression of STAT1 in normal human BJ fibroblasts (Cheon and Stark 2009). Numbers represent the ratios of expression of genes in cells overexpressing wild-type STAT1 (WT) or Y701F STAT1 (YF), relative to cells transfected with empty vector.