FIG. 1.

Interaction of BST-2 with HIV-1 proteins. Vpu interacts with BST-2 through its TM domain. The interaction of HIV-2 Env with BST-2 has not been mapped in detail but involves the ectodomain. Interaction of BST-2 with Nef involves a G/DDIWK in the cytoplasmic domain. This motif is missing in Nef-insensitive BST-2 variants (eg, human BST-2). Proposed interaction points are indicated by zig-zag lines. HIV, human immunodeficiency virus; SIV, simian immunodeficiency virus; TM, transmembrane; Myr, Nef myristoylation; GPI, glycosyl-phosphatidylinositol anchor; BST-2, bone marrow stromal antigen 2.